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Sunday, May 3, 2020 | History

2 edition of Biochemical mechanisms of platinum antitumour drugs found in the catalog.

Biochemical mechanisms of platinum antitumour drugs

Biochemical mechanisms of platinum antitumour drugs

based on the proceedings of a symposium held at Brunel University, July 3-5, 1985

  • 389 Want to read
  • 39 Currently reading

Published by IRL in Oxford, Washington, D.C .
Written in English

    Subjects:
  • Cancer -- Chemotherapy -- Congresses.,
  • Platinum compounds -- Therapeutic use -- Congresses.

  • Edition Notes

    Includes bibliographies and index.

    Statementedited by D.C.H. McBrien and T.F. Slater.
    SeriesAssociation for International Cancer Research symposia -- no.4., Association for International Cancer Research symposia -- no. 4.
    ContributionsMcBrien, D. C. H., Slater, T. F. 1931-
    Classifications
    LC ClassificationsRC271.P55
    The Physical Object
    Paginationxiv, 423 p. :
    Number of Pages423
    ID Numbers
    Open LibraryOL17927599M
    ISBN 100947946470
    LC Control Number86014233

      [Read PDF] Mechanisms of Action of Antiepileptic Drugs Download Free. JamieHolman. Read Book Brain Mechanisms and Psychotropic Drugs (Handbooks in Pharmacology and Toxicology) Lidania. Biochemical Mechanisms of Platinum Antitumour Drugs [Read] Online. Jona. The development of resistance to platinum-based chemotherapy is a major clinical challenge in cancer treatment, since the cellular response which confers resistance to carboplatin is multifactorial and poorly understood (Wernyj, Morin, ; Shahzad, Berestein, Sood, ).It has been observed that the intracellular mechanisms by which cells become resistant to .

      The platinum-based drugs cisplatin, carboplatin, and oxaliplatin belong to the most widely used chemotherapeutics in oncology, showing clinical efficacy against many solid tumors. Their main mechanism of action is believed to be the induction of cancer cell apoptosis as a response to their covalent binding to DNA. In recent years, this picture has increased in Cited by:   The chemical and biochemical consequences of the binding of the antitumour drug cisplatin and other platinum group metal complexes to DNA P. Umapathy Coordination Chemistry Reviews, , Vol Number 2, Page Cited by:

    Platinum complexes are clinically used as adjuvant therapy of cancers aiming to induce tumor cell death. Depending on cell type and concentration, cisplatin induces cytotoxicity, e.g., by interference with transcription and/or DNA replication mechanisms. Additionally, cisplatin damages tumors via induction of apoptosis, mediated by the activation of various signal Cited by: Current Status and Mechanism of Action of Platinum‐Based Anticancer Drugs Shanta Dhar Massachusetts Institute of Technology, Department of Chemistry, Room 18‐, Cambridge, MA Cited by:


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Biochemical mechanisms of platinum antitumour drugs Download PDF EPUB FB2

Biochemical mechanisms of platinum antitumour drugs: based on the proceedings of a symposium held at Brunel University, th July Author: D C H McBrien ; T F Slater.

Writing from a variety of disciplines, these authorities discuss the chemistry of cisplatin in aqueous solution, the molecular interaction of platinum drugs with DNA, and such exciting new areas as DNA mismatch repair, replicative bypass, apoptosis, and the transport of platinum drugs into tumor cells.

The antitumor activity and toxicology of 5/5(1). The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, aiming at the rationalization of the action of this type of drug, which would allow the design of.

Biochemical mechanisms of platinum antitumour drugs: based on the proceedings of a symposium held at Brunel University, JulyAuthor: D C H McBrien ; T F Slater. Platinum-Based Drugs in Cancer Therapy (Cancer Drug Discovery and Development): Medicine & Health Science Books @ 5/5(1).

Abstract: Since the discovery by Rosenberg and collaborators of the antitumor activity of cisplatin 35 years ago, three platinum antitumor drugs (cisplatin, carboplatin and oxaliplatin) have enjoyed a huge clinical and commercial hit. Ever since the initial discovery of the anticancer activity of cisplatin, major efforts have been devoted to elucidate the biochemical mechanisms of antitumor activity of cisplatin in order to be able to rationally design novel platinum based drugs.

Metal Antitumor Compounds: The Mechanism of Action of Platinum Complexes. Abstract. Cisplatin (cis-diamminedichloroplatinum(II)) is widely used in the treatment of testicular and ovarian cancers.

A number of biological and biochemical results indicate that the reaction of cisplatin with DNA is responsible for the cytotoxic action of this by: Platinum compounds constitute a discrete class of DNA-damaging anticancer agents that are now widely used clinically.

The first platinum anticancer drug introduced in the clinic was cisplatin, which has become a major chemotherapeutic agent for the treatment of a wide spectrum of solid tumors, including cancers of the head and neck, testes, ovary, uterine cervix, bladder Cited by:   The four steps of the mechanism of cisplatin and, by extension, related platinum anticancer drugs.

(i) Cellular uptake, (ii) aquation/activation, (iii) DNA binding, and (iv) cellular processing of DNA lesions leading to by: The mechanism of action of these complexes, also known as platinum-based drugs, is based on hydrolysis connected with the replacement of so-called ''leaving groups " (i.e Author: Mark Mckeage.

Platinum anti-cancer drugs: Free radical mechanism of Pt-DNA adduct formation and anti-neoplastic effect. Free Radical Biology and Medicine95, DOI: /dbiomed Jing Li, Lei Yue, Yaqin Liu, Xinchi Yin, Qi Yin, Yuanjiang Pan, Lirong by: Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year.

Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design.

Biochemical Modulation of Cisplatin Mechanisms of Action: Enhancement of Antitumor Activity and Circumvention of Drug Resistance Platinum-Based Antitumor Drugs Containing Enantiomerically Pure α-Trifluoromethyl Alanine as Ligand.

Complexes of glutathione with heavy metal ions as a new biochemical marker of aquatic environment by: Platinum-based antineoplastic drugs (informally called platins) are chemotherapeutic agents used to treat are coordination complexes of drugs are used to treat almost half of people receiving chemotherapy for cancer.

In this form of chemotherapy, popular drugs include cisplatin, oxaliplatin, and carboplatin, but several have been proposed or are. Biochemical and Molecular Mechanisms of Cisplatin Resistance. Authors; Authors and affiliations Sorenson CM. Mechanisms of resistance to platinum drugs. In: Nicolini M (ed.), Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy, Martinus Nijhoff, Boston, MA, –, Siddik Z.H.

() Biochemical and Molecular Cited by: Novel Concepts in the Development of Platinum Antitumor Drugs Curr. Med. Chem. – Anti-Cancer Agents,Vol. 2, No. 4 intercalating DNA-binding with typical binding constants of. The mechanism of action of platinum anti-tumor drugs Jan Reedijk Department of Chemistry, Gor1aeu Laboratories, State University Leiden,RA Leiden, The Netherlands.

Abstract. A discussion is presented on the mechanism of action of platinum amine compounds, used as antitumor drugs. The relationship between biological acitivity. T1 - Cisplatin as an anti-tumor drug. T2 - Cellular mechanisms of activity, drug resistance and induced side effects.

AU - Florea, Ana Maria. AU - Büsselberg, Dietrich. PY - /3/1. Y1 - /3/1. N2 - Platinum complexes are clinically used as adjuvant therapy of cancers aiming to induce tumor cell by: ADVERTISEMENTS: The following points highlight the nine main biochemical mechanisms of action of growth factors of cancer cells.

The biochemical mechanisms are: 1. Progression of Tumors 2. Drugs used in Cancer Chemotherapy 3. P-Glycoprotein Plays an Important Role in Multidrug Resistance in Cancer Chemotherapy 4. Metastasis 5. Isolation of a Number of. 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy.

This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such. Information about the open-access article 'Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects' in DOAJ.

DOAJ is an online directory that indexes and provides access to quality open access, peer-reviewed by: Resistance frequently develops to all three classes of drugs and can be functionally separated into distinct biochemical pathways: (1) relative dose intensity plays a role in resistance to platinum complexes and to a lesser degree with alkylating agents; (2) induction of the membrane P‐ glycoprotein confers resistance to natural products Cited by: been devoted to elucidate the biochemical mechanisms of antitumor activity of cisplatin in order to be able to rationally design novel platinum based drugs with superior pharmacological profiles.

In this report we attempt to provide a current picture of the known facts pertaining to the mechanism of action of theCited by: